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Thursday, October 5, 2017

The Daily Drift

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Carolina Naturally
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Today in History

1762 The British fleet bombards and captures Spanish-held Manila in the Philippines.
Women of Paris march to Versailles in what will become known the March on Versailles to confront Louis XVI of France about his refusal to promulgate the decrees on the abolition of feudalism, demand bread, and have the king and his court moved to Paris.The march will be one of the earliest and most significant events of the French Revolution.
1795 The day after he routed counterrevolutionaries in Paris, Napoleon Bonaparte accepts their formal surrender.
1813 The U.S. emerges victorious at the Battle of the Thames, in Ontario, breaking Britain’s Indian allies with the death of Shawnee Chief Tecumseh, and making the Detroit frontier safe.
1821 Greek rebels capture Tripolitsa, the main Turkish fort in the Peloponnese area of Greece.
1864 At the Battle of Allatoona, a small Union post is saved from Lt. Gen. John Bell Hood‘s army.
1877 Nez Perce Chief Joseph surrenders to Colonel Nelson Miles in Montana Territory, after a 1,700-mile trek to reach Canada falls 40 miles short.
1880 The first ball-point pen is patented by Alonzo T. Cross.
1882 Outlaw Frank James surrenders in Missouri six months after his brother Jesse’s assassination.
1915 Germany issues an apology and promises payment for the 128 American passengers killed in the sinking of the British ship Lusitania.
1915 Bulgaria enters World War I on the side of the Central Powers.
1931 Clyde Pangborn and Hugh Herndon complete the first heavier than air nonstop flight over the Pacific. Their flight, begun October 3, lasted 41 hours, 31 minutes and covered 5,000 miles. They piloted their Bellanca CH-200 monoplane from Samushiro, 300 miles north of Tokyo, Japan, to Wenatchee, Washington.
1938 Germany invalidates Jews’ passports.
1943 Imperial Japanese forces execute 98 American POWs on Wake Island.
1947 US President Harry S Truman delivers the first televised White House address.
1965 U.S. forces in Saigon receive permission to use tear gas.
1966 A sodium cooling system malfunction causes a partial core meltdown at the Enrico Fermi demonstration breeder reactor near Detroit. Radiation is contained.
1968 Police attack civil rights demonstrators in Derry, Northern Ireland; the event is considered to be the beginning of “The Troubles.”
1986 Britain’s The Sunday Times newspaper publishes details of Israel’s secret nuclear weapons development program.
2000 Slobodan Milosevic, president of the Federal Republic of Yugoslavia, resigns in the wake of mass protest demonstrations.

Why people around the world fear climate change more than Americans do

When asked about major threats to their country, Europeans are more likely than Americans to cite global climate change, according to a recent Pew Research Center survey. Just 56 percent of Americans see climate change as a major threat, versus an average of 64 percent of Europeans surveyed.

This Isn’t Just Another Urban Farm

Rare benign tumors hold the ‘genetic recipe’ to combat diabetes

Rare benign tumors known as insulinomas contain a complicated wiring diagram for regeneration of insulin-producing human beta cells, which may hold the key to diabetes drug development, researchers at the Icahn School of Medicine at Mount Sinai report.
The study, titled “Insights into Beta Cell Regeneration for Diabetes via Integration of Molecular Landscapes in Human Insulinomas,” was published in an online study today in Nature Communications.
With the help of an international group of investigators, the Mount Sinai team collected 38 human insulinomas — rare pancreatic tumors that secrete too much insulin — and analyzed their genomics and expression patterns.
“For the first time, we have a genomic recipe — an actual wiring diagram in molecular terms that demonstrates how beta cells replicate,” said Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine and lead author of the study. Approximately 30 million people living in the United States have diabetes and nearly 50 to 80 million are living with prediabetes. Diabetes occurs when there are not enough beta cells in the pancreas, or when those beta cells secrete too little insulin, the hormone required to keep blood sugar levels in the normal range. Diabetes can lead to major medical complications: heart attack, stroke, kidney failure, blindness, and limb amputation.
Loss of insulin-producing beta cells has long been recognized as a cause of type 1 diabetes, in which the immune system mistakenly attacks and destroys beta cells. In recent years, researchers have concluded that a deficiency of functioning beta cells also contributes importantly to type 2 diabetes–the primary type that occurs in adults. Thus, developing drugs that can increase the number of healthy beta cells is a major priority in diabetes research.
“When you think of tumor genomics, you’re thinking of breast cancer or colon cancer, leukemia, et cetera. No one is thinking of doing genomics on tumors that don’t really kill people,” said Dr. Stewart. “So the real innovation here is that we collected benign tumors that don’t metastasize and don’t cause great harm, and we’re trying to use these benign tumors that have beta cell regeneration going on in them, as the only reasonable source of genomic information on how to make beta cells regenerate.”
Knowing where to look is one thing, but in the era of big data, knowing how to look is very important, said Carmen Argmann, PhD, Associate Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and co-author of the paper. “In this case, we looked at millions of data points collected in rare human insulinomas to try and find an answer to a common disease, diabetes. We then computationally created two molecular pictures from that data, one from the insulinoma and one for the normal beta cell, and identified the critical differences that will hopefully lead to new ways to expand beta cell mass in diabetes patients. We plan to explore clinical applications of these new findings in close collaboration with the team at Sema4, a company specializing in big data analytics for diagnostic development.”
In 2015, Dr. Stewart and his team published a paper in Nature Medicine showing that the drug harmine drove the sustained division and multiplication of adult human beta cells in culture, a feat that had eluded the field for years. In addition, they also learned that harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.
According to Dr. Stewart, the results of the harmine study provided a large body of evidence demonstrating that the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment. The new results confirm that harmine is one pathway to beta cell regeneration but also suggest a number of new pathways that can be treated with novel diabetes drugs. “We are excited and gratified by these remarkable results, which reveal an extraordinary array of new and validated pathways for diabetes drug development,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai. “In a very short time, we have made terrific progress, and it is really a credit to the remarkably diverse areas of strength in biomedical research at Mount Sinai. It is truly an exciting set of discoveries for the field of diabetes.”

Scientists grow bones in laboratory with nano particles

Osteoporosis, a disease that weakens bones, is a global epidemic: an estimated 200 million women worldwide suffer bone fractures as a result of the condition. One in three women and one in five men over the age of 50 will experience osteoporosis-related bone fractures. Treatment of the condition and its damage incur a huge amount of healthcare costs every year. New ways to repair and regenerate bone are urgently needed. 

Researchers get first look at electrons escaping atoms

Researchers get first look at electrons escaping atoms
Researchers have—for just a fraction of a second—glimpsed an electron’s-eye view of the world.That is, they have succeeded for the first time in tracking...

ACLU sues over FDA restrictions on abortion pill access

ACLU sues over FDA restrictions on abortion pill access
The American Civil Liberties Union filed a lawsuit on Tuesday seeking to challenge U.S. Food and Drug Administration restrictions that limit the ability of women to access the so-called abortion pill.…

Will Retailers Switch to a Price Tag System That Screws Customers at Every Opportunity?

Fast-moving magnetic particles could enable new form of data storage

Fast-moving magnetic particles could enable new form of data storage
New research has shown that an exotic kind of magnetic behavior discovered just a few years ago holds great promise as a way of...

Yahoo says all 3 billion accounts hacked in 2013 data theft

Yahoo says all 3 billion accounts hacked in 2013 data theft
Yahoo on Tuesday said that all 3 billion of its accounts were hacked in a 2013 data theft, tripling its earlier estimate of the size of the largest breach in history, which already had spawned a nationwide lawsuit.…

Dumbass Trump’s IRS Just Decided They’re Going To Give All Your Info To Equifax After They Got Hacked

Dumbass Trump’s IRS Just Decided They’re Going To Give All Your Info To Equifax After They Got Hacked
Well this is a foolproof plan.

Ways We Can Begin to Rein in Facebook's Immense Power Over Media and Our Society

The Federal Gov't Has Been Paying States to Imprison People

How a Racist Is Made—and Unmade

Jason Kessler -- organizer behind racist 'Unite the Right' rally -- gets indicted for perjury in Virginia

Jason Kessler, the organizer of the so-called “Unite the Right” rally in Charlottesville, Virginia, has been indicted for perjury related to an incident in January. A capias has been issued for his arrest.
A grand jury in Albemarle County issued an indictment for Kessler on a felony perjury charge over a sworn statement he made earlier this year, according to local media outlet CBS19.
Kessler gave a statement to a magistrate claiming that he was assaulted by James Taylor while collecting signatures to have Wes Bellamy removed from the Charlottesville City Council.
But a video later revealed that Kessler was the one who attacked Taylor. Assault charges against Taylor were dropped in March, while Kessler ended up pleading guilty to assault in April.

Pregnant Woman Taunted With Racial Slurs While Walking to Induce Labor in Her Detroit Neighborhood

With No Muslims to Blame, Dumbass Trump the Twitter Troll Has Gone Eerily Silent About the Las Vegas Murderer

Anti-Islam 'hate convention' underway near DC

Rights groups are questioning the underlying intentions of an event billed as “the nation's largest national security-focused grassroots gathering,” which the groups say was sponsored by a “hate group.”
ACTCON 2017: United Against Terror, which ends Tuesday afternoon in Arlington, Virginia—just a stone’s throw from America’s levers of power in Washington, D.C.—is the brainchild of wingnut hardliner Brigitte Gabriel, who is known for warning about what she sees as the dangers of Islam.

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