Welcome to Today's Edition of
Carolina Naturally
Carolina Naturally
Carolina Naturally is read in 210 countries around the world daily.
Ooh, Teacher ... !
You want the unvarnished truth?
Don't forget to visit: The Truth Be Told
Thursday, October 5, 2017
The Daily Drift
Ooh, Teacher ... !
You want the unvarnished truth?
Today in History
| 1762 | The British fleet bombards and captures Spanish-held Manila in the Philippines. | |
| 1789 |  |
|
| 1795 | The day after he routed counterrevolutionaries in Paris, Napoleon Bonaparte accepts their formal surrender. | |
| 1813 | The U.S. emerges victorious at the Battle of the Thames, in Ontario, breaking Britain’s Indian allies with the death of Shawnee Chief Tecumseh, and making the Detroit frontier safe. | |
| 1821 | Greek rebels capture Tripolitsa, the main Turkish fort in the Peloponnese area of Greece. | |
| 1864 | At the Battle of Allatoona, a small Union post is saved from Lt. Gen. John Bell Hood‘s army. | |
| 1877 | Nez Perce Chief Joseph surrenders to Colonel Nelson Miles in Montana Territory, after a 1,700-mile trek to reach Canada falls 40 miles short. | |
| 1880 | The first ball-point pen is patented by Alonzo T. Cross. | |
| 1882 | Outlaw Frank James surrenders in Missouri six months after his brother Jesse’s assassination. | |
| 1915 | Germany issues an apology and promises payment for the 128 American passengers killed in the sinking of the British ship Lusitania. | |
| 1915 | Bulgaria enters World War I on the side of the Central Powers. | |
| 1931 | Clyde Pangborn and Hugh Herndon complete the first heavier than air nonstop flight over the Pacific. Their flight, begun October 3, lasted 41 hours, 31 minutes and covered 5,000 miles. They piloted their Bellanca CH-200 monoplane from Samushiro, 300 miles north of Tokyo, Japan, to Wenatchee, Washington. | |
| 1938 | Germany invalidates Jews’ passports. | |
| 1943 | Imperial Japanese forces execute 98 American POWs on Wake Island. | |
| 1947 | US President Harry S Truman delivers the first televised White House address. | |
| 1965 | U.S. forces in Saigon receive permission to use tear gas. | |
| 1966 | A sodium cooling system malfunction causes a partial core meltdown at the Enrico Fermi demonstration breeder reactor near Detroit. Radiation is contained. | |
| 1968 | Police attack civil rights demonstrators in Derry, Northern Ireland; the event is considered to be the beginning of “The Troubles.” | |
| 1986 | Britain’s The Sunday Times newspaper publishes details of Israel’s secret nuclear weapons development program. | |
| 2000 | Slobodan Milosevic, president of the Federal Republic of Yugoslavia, resigns in the wake of mass protest demonstrations. |
Why people around the world fear climate change more than Americans do
Rare benign tumors hold the ‘genetic recipe’ to combat diabetes
The study, titled “Insights into Beta Cell Regeneration for Diabetes via Integration of Molecular Landscapes in Human Insulinomas,” was published in an online study today in Nature Communications.
With the help of an international group of investigators, the Mount Sinai team collected 38 human insulinomas — rare pancreatic tumors that secrete too much insulin — and analyzed their genomics and expression patterns.
“For the first time, we have a genomic recipe — an actual wiring diagram in molecular terms that demonstrates how beta cells replicate,” said Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine and lead author of the study. Approximately 30 million people living in the United States have diabetes and nearly 50 to 80 million are living with prediabetes. Diabetes occurs when there are not enough beta cells in the pancreas, or when those beta cells secrete too little insulin, the hormone required to keep blood sugar levels in the normal range. Diabetes can lead to major medical complications: heart attack, stroke, kidney failure, blindness, and limb amputation.
Loss of insulin-producing beta cells has long been recognized as a cause of type 1 diabetes, in which the immune system mistakenly attacks and destroys beta cells. In recent years, researchers have concluded that a deficiency of functioning beta cells also contributes importantly to type 2 diabetes–the primary type that occurs in adults. Thus, developing drugs that can increase the number of healthy beta cells is a major priority in diabetes research.
“When you think of tumor genomics, you’re thinking of breast cancer or colon cancer, leukemia, et cetera. No one is thinking of doing genomics on tumors that don’t really kill people,” said Dr. Stewart. “So the real innovation here is that we collected benign tumors that don’t metastasize and don’t cause great harm, and we’re trying to use these benign tumors that have beta cell regeneration going on in them, as the only reasonable source of genomic information on how to make beta cells regenerate.”
Knowing where to look is one thing, but in the era of big data, knowing how to look is very important, said Carmen Argmann, PhD, Associate Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and co-author of the paper. “In this case, we looked at millions of data points collected in rare human insulinomas to try and find an answer to a common disease, diabetes. We then computationally created two molecular pictures from that data, one from the insulinoma and one for the normal beta cell, and identified the critical differences that will hopefully lead to new ways to expand beta cell mass in diabetes patients. We plan to explore clinical applications of these new findings in close collaboration with the team at Sema4, a company specializing in big data analytics for diagnostic development.”
In 2015, Dr. Stewart and his team published a paper in Nature Medicine showing that the drug harmine drove the sustained division and multiplication of adult human beta cells in culture, a feat that had eluded the field for years. In addition, they also learned that harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.
According to Dr. Stewart, the results of the harmine study provided a large body of evidence demonstrating that the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment. The new results confirm that harmine is one pathway to beta cell regeneration but also suggest a number of new pathways that can be treated with novel diabetes drugs. “We are excited and gratified by these remarkable results, which reveal an extraordinary array of new and validated pathways for diabetes drug development,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai. “In a very short time, we have made terrific progress, and it is really a credit to the remarkably diverse areas of strength in biomedical research at Mount Sinai. It is truly an exciting set of discoveries for the field of diabetes.”
Scientists grow bones in laboratory with nano particles
Researchers get first look at electrons escaping atoms
Researchers have—for just a fraction of a second—glimpsed an
electron’s-eye view of the world.That is, they have succeeded for the
first time in tracking...
ACLU sues over FDA restrictions on abortion pill access
Fast-moving magnetic particles could enable new form of data storage
New
research has shown that an exotic kind of magnetic behavior discovered
just a few years ago holds great promise as a way of...
Yahoo says all 3 billion accounts hacked in 2013 data theft
Jason Kessler -- organizer behind racist 'Unite the Right' rally -- gets indicted for perjury in Virginia
A grand jury in Albemarle County issued an indictment for Kessler on a felony perjury charge over a sworn statement he made earlier this year, according to local media outlet CBS19.
Kessler gave a statement to a magistrate claiming that he was assaulted by James Taylor while collecting signatures to have Wes Bellamy removed from the Charlottesville City Council.
But a video later revealed that Kessler was the one who attacked Taylor. Assault charges against Taylor were dropped in March, while Kessler ended up pleading guilty to assault in April.
Anti-Islam 'hate convention' underway near DC
Rights groups are questioning the underlying intentions of an event
billed as “the nation's largest national security-focused grassroots
gathering,” which the groups say was sponsored by a “hate group.”ACTCON 2017: United Against Terror, which ends Tuesday afternoon in Arlington, Virginia—just a stone’s throw from America’s levers of power in Washington, D.C.—is the brainchild of wingnut hardliner Brigitte Gabriel, who is known for warning about what she sees as the dangers of Islam.
Subscribe to:
Posts (Atom)
