There are 44 prescription drugs on the market today that should
never be combined with grapefruit. That's because the sour fruit (and
some other, closely related, kinds of citrus) contain chemical compounds
called furanocoumarins that prevent your body from metabolizing certain
prescription drugs. Essentially, the grapefruit creates an artificial
overdose where one tablet packs the power (and side effects) of 20.
The CBC has a full list of the drugs,
which includes cancer drugs, cholesterol-lowering drugs, and drugs to
treat problems of the urinary tract. Wikipedia has more about
why this interaction happens.
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